Sentence examples for monitoring boundaries were from inspiring English sources

Trial sequential monitoring boundaries were employed to control the risks for type I and II errors, and to indicate whether additional trials are needed.

Trial sequential analysis showed that only 1.18% of the required information size to detect or reject a 10% relative risk reduction was accrued, and the trial sequential monitoring boundaries were not crossed (figure 2C).

Trial sequential analysis showed that only 3.84% of the required information size to detect or reject a 10% relative risk reduction was accrued so far, and the trial sequential monitoring boundaries were not crossed (figure 4B).

Trial sequential analysis showed that 34.8% of the required information size to confirm the observed difference between the interventions was accrued, and the trial sequential monitoring boundaries were not crossed (figure 8B).

Trial sequential analysis showed that only 0.84% of the required information size to detect or reject a 10% relative risk reduction was accrued, and the trial sequential monitoring boundaries were not crossed (see web appendix 3, figure 9).

TSA indicated lack of reliable and conclusive evidence for a beneficial effect of MIH for both mortality (Fig.  2a) and a poor neurological outcome (Fig.  2b), since the monitoring boundaries were not finally surpassed and the required information size was not reached.

22 Trial sequential monitoring boundaries are used to control the risks for type I and II errors and to indicate whether additional trials are needed.

Trial sequential analysis is similar to interim analysis in a single trial where the monitoring boundaries are used to decide whether the P value is sufficiently small to show the anticipated effect and whether the trial should be terminated early.

26 27 This is similar to interim analyses in a single trial, where monitoring boundaries are used to decide whether a trial could be terminated early when a P value is sufficiently small to show the anticipated effect.

In this context, the smaller the required information size the more lenient the trial sequential monitoring boundaries are and, accordingly, the more lenient the criteria for statistical significance will be.

If the O'Brien-Fleming monitoring boundary is exceeded the trial is terminated.