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Their limitations include multiple food and drug interactions and need for frequent monitoring and dose adjustments.
Vancomycin levels are kept within target range by therapeutic monitoring and dose adjustment according to renal function.
Busulfan pharmacokinetics showed high inter- and intraindividual variability in HSCT using a targeted busulfan/fludarabine regimen, which indicates the need for intensive monitoring and dose adjustment to improve the outcome of HSCT.
Novel oral anticoagulants have the potential to improve stroke prevention in patients who have atrial fibrillation and an elevated risk of stroke by overcoming several limitations of warfarin, such as the need for regular monitoring and dose adjustment, and the existence of multiple drug interactions and dietary restrictions.
Monitoring and dose adjustment for OAT is managed by general practitioners in Germany.
Like VKAs, unfractionated heparin also requires frequent monitoring and dose adjustment.
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On the other hand, VKAs require regular INR monitoring and dose-titration over the duration of therapy.
An agent with these properties could be given in fixed doses, eliminating the need for monitoring and dose-titration that are necessary for VKAs.
Vancomycin monitoring and dosing varied according to the standards at each institution.
Water conditions in our facility (pH = 7.1-7.4; temperature = 26.5-28.5°C 26.5-28.5°Cty = 490–530 μS; and dissolved oxygen conductivityn = 5.0-7.5 mg L-1 were rigorously maintained through real-time computerized monitoring and dosing.
3 This included the terms tailored, drug monitoring, personalised and dose adjustment, and a protocol for the review was produced.
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tracking and dose
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monitoring and dosing
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monitoring and quality
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