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During infusion patients were monitored with serial assessments of the following symptoms (nausea, vomiting, fever, giddiness, numbness of hands or feet, flushing of face, difficulty breathing, cough, pain at infusion site, rash, WHO dangers signs [21] and vital signs (systolic and diastolic blood pressure, pulse rate, respiratory rate, temperature) at 10 minute intervals.
Surgical outcome was monitored with serial optical coherence tomography (OCT).
The postoperative progress was monitored with serial visual acuity and spectral domain OCT monitoring.
Over the first 36 hours, pulmonary adaptation can be monitored with serial ultrasound scans.
Patients were monitored with serial FET PET scans (2 12 scans).
The patients were monitored with serial transvaginal ultrasound and E2 levels to monitor their follicular growth and endometrial lining.
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Because of preclinical data in dogs suggesting cardiac toxicity, patients were monitored with continuous cardiac monitoring, serial cardiac enzymes, electrocardiography (ECG), and nuclear ventriculography.
While the clinician may be relatively comfortable with the prospect of monitoring this with serial imaging to confirm stability or regression as indicators of a benign process, the intervening period is necessarily filled with anxiety for the patient, particularly if further investigation by way of biopsy is recommended.
The one positive screening MUGA scan in patients who were less than 40 years old prompted a monitoring with serial MUGA scan (one scan after each dose).
Limited data suggests that serial monitoring with serial histoplasma serologies or urinary histoplasma antigen testing in a highly endemic area is not helpful to identify these patients before the onset of symptomatic disease [ 7].
These other trials did not look at cardiotoxicity in detail and it was therefore reassuring for us to find no evidence of increased subclinical cardiotoxicity monitored by serial LVEF with the accelerated vs standard approach in our study.
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