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In the past, doctors monitored trial participants mainly by seeing them periodically in their offices.
"The only large-scale trial we may see is the enormous but uncontrolled and poorly monitored trial of people using these drugs on their own".
A carefully monitored trial of these agents with documented positive clinical response using objective measures can be considered.
Only then should those who are not known to have an absent or dysplastic thyroid gland undergo carefully monitored trial withdrawal of therapy[ 10].
However in everyday clinical practice, as opposed to a closely monitored trial overall compliance may be lower, although the enthusiasm of the relevant clinician may have a role as discussed above.
Despite the results of the HDHK pilot study, efficacy was established in a university-based research project that was delivered by highly qualified staff in a closely monitored trial.
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The Organization for Security and Coöperation in Europe monitored trials in Chisinau for six months in 2006.
He is also sympathetic to strictly monitored trials of heroin prescribing.
"When I and colleagues have monitored trials we have always observed serious flaws in the security and reliability of the systems used," he said.
A power analysis was conducted using simulations of continuously monitored, trial-stopping boundaries to determine the accrual buffer needed to suspend a trial after an adverse event (7).
Predictors of enhancement status could be useful for the selection of patients for MRI monitored trials.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com