Monitored end-points included body and renal weights, urine volume, renal histology and ultrastructural pathology, serum urea nitrogen and creatinine, selected serum and urine cytokines, and renal mercury concentrations.
The incubation time for condyloma is on average about three months, and a decline in these readily apparent lesions is an early monitoring end point for confirming that HPV vaccination programmes have had an important effect at the population level.
Confidence in results from monitoring genetic end points in environmentally or occupationally exposed individuals can be improved with knowledge of the normal variability of changes in genetic end points in the general population.
Our intention was to perform a bleeding-resuscitation experiment with detailed hemodynamic monitoring, predefined end points, and a pragmatic protocol.
Totally 832 participants eligible for stent placement were enrolled and followed up for monitoring clinical end points.
They responded by positioning a mouse driven cursor on a colored histogram, displayed on a computer monitor, with end points labeled very good/very poor for each of four attributes of voice or fluency depending upon the listener's area of expertise.
Behavior of a biological system, e.g., as a result of disease progression or as effect in response to therapy, can be monitored by measuring surrogate end points such as key physiological time series responses.
Conventionally, the residual activity is monitored through an end point radiolabelled CO2 trapping assay [ 16, 17].
An independent data safety monitoring board monitored clinical outcomes and safety end points throughout the trial.
The objective of this study was to compare warfarin-related monitoring outcomes, clinical end points, and the use of health-care resources as a result of warfarin-related complications in anticoagulation clinic patients whose management was conducted by telephone or in-office-based visits.
To improve the outcome of melanoma treatments and to determine the biological mechanisms of efficacy or failure, future studies with small molecules and targeted therapies will also require strict monitoring of biological end points.
