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We have investigated sterol-hormone interactions through the analysis of double mutants in sterol synthesis and ethylene responses, and monitored effects on PIN proteins and auxin-regulated genes, including a key gene, AtHB8, which is an auxin-regulated transcription factor required for vascular development.
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Moreover, few studies have incorporated interventions after an AAA is established and monitored effects of interventions on AAA progression.
Numerous studies have monitored effects of copper deficiency on immune function in animal models.
Need to monitor effects on public health: The public health effects of the Exxon Valdez on clean-up workers and residents is largely unknown.
Selected hits were then subjected to detailed analysis by monitoring effects on tandem-LC3, GFP-Rab7, and LTR.
Factors such as age, season and nutritional status must be taken into account when monitoring effects on the reproductive system in the wild mink.
Previous analysis of such mutations has largely been restricted to monitoring effects on integrin activation, and not cellular responses such as cell spreading or FA assembly.
Some of the small molecule VEGFR-3 inhibitors are already in clinical trials, however, these trials are not specifically designed to monitor effects on metastasis.
In view of the growing recognised role of angiogenesis in oncology, and the integration of drugs targeting tumour vasculature, biomarkers that enable monitoring effects on vasculature are urgently needed.
In order to monitor effects on proliferation, cells were stimulated simultaneously with Δ4A and treated for 24 hours with both agents alone or in combination before processing for Western blotting.
Addressing these two experimental issues, by optimizing conditions, testing more compounds, and monitoring effects on multiple kinases, would require substantial efforts and unnecessarily further delay the publication of our central findings regarding mutual exclusivity and synthetic lethality.
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