Sentence examples for monitored by phosphorylation from inspiring English sources

SIN-1 increased the activity of PI3-kinase, as monitored by phosphorylation of Akt.

Activation of mTOR can be monitored by phosphorylation of its downstream targets and so we looked at the mTOR substrate p70-S6Kinase (p70S6K) and its substrate ribosomal protein S6 (rpS6) due to their established role directly downstream of the mTOR kinase.

The activity of MTORC1 can be monitored by phosphorylation changes in downstream target proteins like RPS6KB and EIF4EBP1.

Activation of NF-κB signalling was monitored by phosphorylation and degradation of IκB, which is necessary for nuclear translocation of NF-κB.

Since insulin activates eNOS through IRS1 and Akt pathway, we then investigated whether FABP4 have any effects on insulin-stimulated IRS1 and Akt activation, which was monitored by phosphorylation at Tyr and Ser sites, respectively.

Ectopic expression of Sesn1 or Sesn2 in different experimental settings results in strong inhibition of TORC1 activity, monitored by phosphorylation of p70S6K, 4E-binding protein (4EBP 1 and S6 proteins (Budanov & Karin, 2008).

Survival signaling monitored by IGFIR phosphorylation, levels of insulin receptor substrates 1 (IRS1) and 2 (IRS2) and Akt phosphorylation, was reduced in APAP-treated wild-type primary hepatocytes, but preserved in PTP1B−/− cells.

This change in Kog1 localization is determined to correlate to varying degrees with Kog1-dependent phosphorylation by Snf1, the presumptive ortholog of AMPK in yeast, and decreased TORC1 activity during glucose starvation, as monitored by Sch9 phosphorylation.

GSK3 inhibition was monitored by GSK3 phosphorylation on inhibitory residues Ser21 (GSK3α) and Ser9 (GSK3β) as this is known to correlate with a reduction in GSK3 activity [22].

(Activation of the hybrid chimeras was monitored by STAT1 phosphorylation).

Efficiency of MTOR knockdown was monitored by measuring phosphorylation of downstream effector protein RPS6.