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In this way we could monitor the pathways showing a global transcriptional perturbation upon silencing of PSCA.
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However, to design a better therapeutic platform it is necessary to monitor the pathway undertaken by these nanostructures once they cross the plasma membrane.
Not only that, but other genetic tweaks make the neurons actually emit light when active, so the optrode can both influence and monitor the steering pathways.
To monitor the reaction pathways, isotope exchange experiments were conducted by using 15NO to react with 14N-nitrate covered catalyst surfaces.
To monitor the transmission pathways of measles virus, we observed the geographic distribution of genetic groups, as well as changes in them in a particular region over time.
The use of dendritic cells to monitor the indirect pathway of alloreactivity should help to design and understand interventions against acute and chronic transplant rejection.
Because cells died faster in mitosis when TRAIL was added, we could not use mitotic exit to monitor the slippage pathway.
The Gluc assay provides a fast, quantitative and sensitive technique to monitor the secretory pathway and ER stress and its compatibility with high throughput screening will allow discovery of drugs for treatment of conditions in which the ER stress is generally induced.
A further advantage of using MS for such applications is that it can be used to elucidate and monitor the metabolic pathway of a substrate and its intermediates active in metabolism, by labeling them with stable C isotopes.
The last advances in several approaches, which use NMR: (i) to monitor the protein folding pathway and/or, (ii) to characterize the structure of the intermediate states in such reaction are reviewed in this work.
It appears that the immunocytochemical methods applied in this and other studies [ 11– 17, 17, 22, 39] do not monitor the neuronal secretory pathway of APP processing leading to normal secretion of Aβ1 40 and Aβ1 42.
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