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We further developed optical imaging to temporally and spatially monitor the biodistribution of DTCSH.
11 Therefore, it is important to monitor the biodistribution of nanoparticles to better understand the biodistribution of the encapsulated drug.
The ability to image and monitor the biodistribution, viability and possibly the differentiation status of implanted SCs is of massive clinical and research benefit.
A major concern for PET imaging to monitor the biodistribution of NPs is whether the radionuclide signal could truly reflect the distribution of nanoparticles.
Positron emission tomography (PET) and fluorescence imaging are commonly available as noninvasive methods to monitor the biodistribution of nanoparticles in mice [ 5, 6].
F-labeled GCase (40) was obtained in a total synthesis time of about 2.5 h in a specific activity of ∼2 GBq/ μmol and was used to monitor the biodistribution of GCase in mice.
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Additionally, we monitored the biodistribution of 68Ga-labelled peptides in CHL-GLP-1R-positive tumour-bearing CD1 nu/nu mice.
The labeling of cells with IONPs allows to noninvasively monitor the migration, biodistribution, and behavior of targeted cells.
MR imaging was used longitudinally to monitor the trafficking and biodistribution of B cells labeled with both SPIO and NIR815 or NIR815 only (i.e. SPIO-free).
This work was initiated to monitor the immediate and realtime biodistribution of viruses in the seconds and minutes after i.v. injection, when reporter gene tracking is not feasible.
Theranostics provide a unique signature for improved staging of the tumour, for imaging of the biodistribution of the target to predict the biodistribution of the radiation dose and to individually monitor the efficacy of treatment with the same basic compound that is being used to target and treat the disease [60].
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