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To date, there is no clinically available tool to monitor mitochondrial function.
These results may contribute to the development of a clinical device to monitor mitochondrial function in the critically ill.
Therefore, in their review, Jeger et al. [ 9] concluded that "… in order to get a better understanding about mitochondrial dysfunction in sepsis a valid non-invasive method to monitor mitochondrial function in vivo would be necessary".
Although our implementation of the PpIX-TSLT is an important step towards addressing the need for a valid noninvasive method to monitor mitochondrial function in vivo, as proposed by Jeger et al. [ 9], some questions still remain.
Given that SMI seems to be a predictor of CVD driven by increased cardiovascular risk markers, it may be of relevance to monitor mitochondrial function as a marker of the appearance and prevalence of SMI.
A method developed to measure the mitochondrial oxygen tension (mitoPO2) using the protoporphyrin IX-triplet state lifetime technique (PpIX-TSLT) [ 20, 21] provides new opportunities to monitor mitochondrial function in vivo.
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A non-invasive method for monitoring mitochondrial function might help overcome this limitation.
The RTG is a signalling pathway responsible for monitoring mitochondrial function and for inducing nuclear responses during times of mitochondrial stress.
Techniques now exist to monitor mitochondrial bioenergetic function in cells with comparable precision to previous studies with isolated mitochondria.
Cutaneous mitochondrial respirometry: non-invasive monitoring of mitochondrial function.
Moreover, because this technique is noninvasive and safe for application in humans [ 26], the PpIX-TSLT may enable clinical monitoring of mitochondrial function at the cellular level.
More suggestions(15)
monitor mitochondrial depolarization
monitor hepatic function
monitor mitochondrial transmembrane
monitor mitochondrial division
monitor thyroid function
monitor microcirculatory function
monitor diaphragmatic function
monitor neuromuscular function
monitor mitochondrial degradation
monitor renal function
monitor mitochondrial superoxide
monitor postoperative function
monitor mitochondrial half-life
monitor cardiac function
monitor mitochondrial quality
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