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The ability to impartially monitor metabolic transformations from a variety of biological sources has also allowed metabolomics to thrive within the context of enzyme function discovery, typically in combination with recombinant genetic and protein expression tools.
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PET scans and functional-magnetic-resonance-imaging machines have helped address the problem; they permit neuroscientists to monitor metabolic changes and blood flow in the human brain.
These generic metabolites represent whole classes of structurally similar metabolites that undergo the same metabolic transformations in vivo.
The studies presented here provide evidence that the remaining approximately 25% of the metabolic transformations are catalyzed by flavin-containing monooxygenase (FMO).
Reactor cycle studies demonstrate that the three sludges carried out metabolic transformations typical of EBPR (Table 1, Fig. S1).
H-MRS is useful to monitor metabolic changes after treatment.
We still lack such tools to monitor metabolic resistance.
Metabolic transformations of selected pesticides illustrating various types of reactions in plants and animals are discussed.
Obviously, metabolic transformations of pharmaceuticals can profoundly impact their bioavailability, efficacy and chronic toxicity, and both the parent molecule and the products of metabolic transformations can interfere with endogenous metabolism [ 6].
The connectivity of a gene is a reflection of its understood prominence in the metabolic network, as measured by the number of discrete metabolic transformations it enables.
These and other anticancer mechanisms ascribed to organoselenium compounds are markedly dependent on their chemical forms and metabolic transformations.
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