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PET scans and functional-magnetic-resonance-imaging machines have helped address the problem; they permit neuroscientists to monitor metabolic changes and blood flow in the human brain.
From these findings, we speculated that RT-MT may be applicable to chemical biological research [59], [60] as well as to silent phenotype analysis [61] to screen for objective chemicals and phenotypes, because RT-MT can easily monitor metabolic changes based on specific reactions and responses by the addition of several compounds.
H-MRS is useful to monitor metabolic changes after treatment.
Indirect calorimetry is recommended for all critically ill patients, to measure their energy requirements and to monitor metabolic changes during the course of critical illness.
One of the intentions with this study was to simultaneously monitor metabolic changes over time in the brain and in the spinal cord.
We show that MRS can monitor metabolic changes after SCI, even in small structures such as the rat spinal cord, and that the method detects changes distant to the site of primary damage, such as in the cerebral cortex with good predictability.
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It is also possible to quantify uptake in absolute units, a factor that may increase sensitivity when monitoring metabolic changes after treatment, with a reduction in uptake correlating with tumour regression and a high initial uptake predicting a poorer outcome [ 2].
Functional MRI (fMRI) is a noninvasive technique which can be used to monitor metabolic activity changes in brain [ 20].
To evaluate the different radiotherapy responses with or without AGuIX administration, 18F-FDG PET/CT imaging was performed to monitor the metabolic changes after irradiation with or without AGuIX injection at two different dosages.
NMR-based metabonomics provides this alternative, as it integrates the responses of all different organs to the altered GHR signalling on a whole-body level and thus offers a direct, cost-effective and non-invasive avenue to monitor actual metabolic changes in a subject over several months.
This enabled monitoring of metabolic changes following the administration of bicuculline, a GABA-A receptor antagonist.
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