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This drug evaluation system enables us to monitor drug effects in photoreceptor cells and could be useful for drug screening.
These data suggest that APLP1 peptides may be used as biomarkers to monitor drug effects of GSMs on γ-secretase processing in clinical trials.
The mechanically loaded PTOA mouse model combined with IVIS scanning provides a means to monitor drug effects using this treatment method longitudinally without animal sacrifice [ 28].
We assessed the retinal biocompatibility of NB30, NB54 and PTC124 in organotypic retina cultures, which serve as reliable tools to monitor drug effects on the retina (Goldmann et al, 2010, 2011; Maerker et al, 2008; Orisme et al, 2010; Reidel et al, 2008).
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Leukemia was one of the first diseases in which DNA microarray technology was applied for monitoring drug effects by analyzing the effect of ATRA treatment in APL-derived cell lines.
Furthermore, the ketamine experiment demonstrates the high sensitivity and temporal resolution of the OKR in monitoring drug effects on CNS function.
Our study is the first to have examined the effect of BK channel inhibitors on heart rate by monitoring drug effects within animals, and in the isolated heart, using a range of paxilline concentrations.
Furthermore, the observed trend of increasing cystatin C levels in patients with slow rates of clinical deterioration may prove to be useful as an objective biomarker for monitoring drug effects in clinical trials.
Such biomarkers may serve as a means of distinguishing ALS from mimic disorders, for the purposes of prognostication, disease monitoring, and monitoring drug effects in treatment trials.
We monitored drug effects on spontaneous contractile activity and, in selected cases, on action potentials (sharp microelectrode) and Ca2+ transients (Fura-2) and contraction under electrical pacing.
A concept of combining markers to improve accuracy has been widely supported, where some candidate biomarkers may be useful to aid in the diagnostics but may also have better applications in monitoring drug effects in clinical trials and as prognostic indicators of disease (for review see [ 22]).
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