This requires new MRI contrast mechanisms, strategic encoding and reconstruction schemes, physiological monitoring, brain tissue modeling and validation.
The scope of this research involves engineering new MRI contrast mechanisms, strategic encoding and reconstruction schemes, physiological monitoring, brain tissue modeling and validation.
A third microdialysis catheter (CMA 70, M Dialysis AB, Stockholm, Sweden) was inserted 20 mm into the left parietal lobe and one probe for monitoring brain tissue oxygenation (PbtO2) (Licox CC1SB, Integra Neurosciences Ltd., NJ, USA) was introduced 15 mm into the contralateral parietal lobe.
In addition, we monitored brain tissue pH to exclude human cases with prolonged terminal hypoxia [26].
Besides intracranial pressure (ICP) monitoring, brain tissue oxygenation (pbtO2) monitoring with the Licox system (Integra Neuroscience, Germany) is on the verge of clinical routine in acute brain injury.
NIRS is predominantly used for monitoring brain tissue oxygen saturation during cardiac surgery and a decrease by more than 20% from baseline is regarded as critical [ 8, 9].
The invasive monitoring of brain tissue oxygenation allows regional and continuous monitoring of PtiO2, which may detect early changes in cerebral tissue oxygenation that precede ischaemic damage.
Monitoring of brain tissue oxygenation using near-infrared spectroscopy has been proposed [46].
Increasing clinical evidence suggests that multimodal brain monitoring, including brain tissue oxygen tension (PbtO2), cerebral microdialysis (CMD), transcranial Doppler (TCD) among others, may optimize CBF and the delivery of oxygen and energy substrates to the injured brain in individual patients.
Growing clinical evidence demonstrates that so-called multimodal brain monitoring, including brain tissue oxygen (PbtO2), cerebral microdialysis and transcranial Doppler among others, might help to optimize CBF and the delivery of oxygen/energy substrate at the bedside, thereby improving the management of secondary brain injury.
