Given the wealth of structural information available for the class I PI3Ks, approaches such as tethering (Hyde et al., 2003; Raimundo et al., 2004; Sadowsky et al., 2011) could be taken to develop small molecule inhibitors that would lock the enzyme in the closed state.
To accomplish this, the team genetically altered the fat cells of mice so that a certain chemical would lock on to a molecule inside fat cells, setting off a chain reaction that compels the cells to commit suicide.
Mars has xenon in its atmosphere, and xenon atoms are similar enough to methane molecules that a physical process which locked up methane would lock up xenon too.
The classical model suggests that SRP binding would lock the ribosome into a conformation that is incompatible with the binding of other molecules called translational factors, which are needed for translation of the messenger RNA to occur (Halic et al., 2004).
It would lock the underfunding into the system forever".
This would lock in the benefits of reform and simultaneously address charges of policy incoherence.
A variationally correct element would lock; to make an element free of locking, some degree of variational incorrectness must be brought in.
We'd lock the door for them and leave.
