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Her software, Méthode d'Inférence, crunches research on hormones and the 1,500 types of receptor molecules with which they interact.
Hence, this approach drastically reduces the number of molecules with which the activity of a target is to be studied.
This appears to be an important energetic requirement in absence of the partner molecules with which the SH3 domain interacts, which were not included in the calculations.
He believes that a snapshot of a protein's structure, isolated from the other molecules with which it interacts, reveals little about its function, an issue that continues to generate debate in the structural biology world.
Despite the recent unveiling of its atomic structure (Akey et al., 2014), and a growing list of host molecules with which it has been found associated, the primary function of NS1 remains elusive.
Since there is no increase in Cdc45 levels during S-phase (Fig. 3C), and Cdc45 is highly stable for the duration of S-phase, we conclude from these results that mammalian cells have a continual presence of a low number of stable Cdc45 molecules with which they start, progress through, and conclude S-phase.
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In this type of circuit, a regulator protein acts to coordinately repress the expression of effector genes when a signal molecule with which it interacts is present.
During HR, the chromosome carrying the DSBs must enter into synapses with an undamaged molecule with which it shares extensive homology and copies the nucleotide sequence around the break.
To this end, we start by shifting focus from the abstract concept of the gene to that very concrete molecule with which we have become so familiar, the DNA.
Such sites inform the developmental process by securing the location of molecules with particular catalytic properties in close proximity to other molecules (or other parts of the DNA molecule) with which they can either interact directly or prevent interaction with other molecules.
If a chosen molecule is forming a complex, then it is removed, but the molecule with which it forms a complex is not removed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com