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In fact, even molecules with very low partition coefficients can penetrate the membrane if they are small enough.
To ensure that these strategies are broadly applicable rather large test-sets of molecules with very diverse molecules are used.
Capture of an IgG in these procedures relies chiefly on its interaction with one of a variety of reengineered bacterial receptors which bind to the Fc region of IgG molecules with very high affinity.
A key structure function relationship involving mirror-image molecules with very differing experimentally determined tumorigenic potencies has been deduced: the members of the pairs align oppositely when bound to DNA, making it likely that their treatment by replication and repair enzymes differ.
It also doesn't explain why odor molecules with very similar shapes give us such different smells; the molecules that gives us the smell of vodka and rotten eggs are almost identical, for example.
To illustrate this point 10 ligands bound to their target protein in a folded conformation were identified by searching the Protein Databank for small molecules with very low correlation coefficient between through-space distance between atom pairs in the 3D-structure of the conformer and the corresponding atom pair topological distances in the parent 2D-structure (Additional file 1: Figure S10).
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The polymer consists of a chain of carbon atoms with two fluorine atoms bonded to each carbon: The fluorine atoms surround the carbon chain like a protective sheath, creating a chemically inert and relatively dense molecule with very strong carbon-fluorine bonds.
Evidence has shown that the scFv of the CAR molecule with very high affinity is inversely correlated with the T cell activation threshold and does not necessarily improve antitumor efficacy (Chmielewski et al., 2004; Hudecek et al., 2013).
The enzyme then changes shape again and forces these molecules together, with the active site in the resulting "tight" state (shown in pink) binding the newly produced ATP molecule with very high affinity.
Our simplified representation does not lose much accuracy: given the torsion angles, we can rebuild the atom coordinates of an RNA molecule with very good accuracy.
HLA-G is a molecule with very low polymorphism and it is generally considered tolerogenic because of its role in maternal-foetal tolerance [ 65] and graft acceptance [ 66].
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