Sentence examples for molecules with enhanced from inspiring English sources

The affinity ligands utilized range from biological to synthetic designed molecules with enhanced resistance and stability.

Developed models and Docking methods provide guidance to design molecules with enhanced activity.

Fragment-based drug design (FBDD) is a promising approach for the generation of lead molecules with enhanced activity and especially drug-like properties against therapeutic targets.

To develop more potent small molecules with enhanced free radical scavenger properties, we designed and synthesized a series of nitronyl nitroxide derivatives 4a h.

Together with a computer-aided interpretation of existing structure-activity relationships of Amaryllidaceae alkaloids congeners, we provide a rationale for designing molecules with enhanced potencies and reduced toxicities.

This comparative study is proposed as a basis for designing new molecules with enhanced anti-proteolytic activities, and no or reduced side-effects, for use in hindering inflammation, cancer invasion and angiogenesis.

Although a number of synthetic modifications of curcumin have been studied intensively in order to develop a molecule with enhanced bioactivities, few synthetic studies were done for the improvement of pharmacokinetic profiles.

These observations led to the hypothesis that increasing the carbohydrate content, beyond that found naturally, would lead to a molecule with enhanced biological activity.

Hence, molecules with an enhanced capacity to reduce PGE2 in cancer cells are of great interest.

Schmidt and colleagues [ 61] demonstrated that muscle fibers expressing MHC class I, taken from patients with inclusion-body myositis, caused an upregulation of ICOS-ICOS-L molecules in association with enhanced perforin expression by autoinvasive CD8+ T lymphocytes, which could exert a cytotoxic effect.

Here, we report that HIFU treatment can cause the release of endogenous danger signals (ATP and hsp60) and exposure of dendritic cells (DCs) and macrophages to the supernatants of HIFU-treated tumor cells leads to an increased expression of co-stimulatory molecules (CD80 and CD86) with enhanced secretion of IL-12 by the DCs and elevated secretion of TNF-alpha by the macrophages.