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Chemokines are a family of structurally-related cytokine molecules with diverse biological functions, including control of angiogenesis.
Lipid biology continues to emerge as an area of significant therapeutic interest, particularly as the result of an enhanced understanding of the wealth of signaling molecules with diverse physiological properties.
Apart from their hepatic functions bile acids are ubiquitous signalling molecules with diverse systemic effects mediated by either the nuclear receptor FXR or by a recently discovered G-protein coupled receptor TGR5.
Over-expressed anti-inflammatory genes identified encode molecules with diverse functions: the anti-inflammatory cytokine IL-10, a putative marker of severe dengue [11], serine proteases and metalloprotease inhibitors, IL-1β cytokine decoy receptor, free heme scavenger molecules, or complement-regulating receptors.
Such data promises to provide knowledge about new enzymes and molecules with diverse applications.
Plants are natural repositories of molecules with diverse structure and function.
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The Sigma-1 receptor (S1R) largely localized to the endoplasmic reticulum (ER) serves as a pluripotent intracellular signaling molecule with diverse roles in the cell including ion channel modulation, stress signaling, and transcriptional regulation (reviewed in Su et al., 2016), however, the basic topology of this protein within a cell remains controversial.
The cyclic dinucleotide c-di-GMP is a signaling molecule with diverse functions in cellular physiology.
RAGE (receptor for advanced glycation end products), a member of the immunoglobulin superfamily of cell surface molecules, interacts with diverse ligands, including not only advanced glycation end products (AGEs) and β-sheet fibrils, but also several members of the S100 protein family (S100B, S100P, S100A4, S100A6, S100A8/9, S100A11 13), high mobility group box-1 (HMGB1), and prions [ 9, 10].
They are present in diverse RNA molecules with various fundamental functions in the cell.
These elements function as building blocks in the design of diverse RNA molecules with various fundamental functions in the cell.
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