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Mass spectrometry is however inherently dispersive, allowing the specific interrogation of molecules with distinct mass-to-charge ratios.
In humans, natural bispecific antibodies are believed to be relevant to the IgG4 subclass, and half-molecule exchanges between 2 IgG4 molecules with distinct specificities are used to explain such natural bispecificity [5].
Several heteroduplex joint molecules with distinct properties form during meiosis, including displacement-loops and dHJs (Keeney and Neale, 2006).
In order to reconstitute two independent DNA duplex strands, all domains of life have evolved a collection of structure-selective endonucleases which cleave DNA joint molecules with distinct substrate specificity (Table 1).
Especially the identified regulators of proinflammatory cytokine signaling (IRAK3, CIAS) and molecules with distinct immunregulatory properties in controlling autoreactive T-cells (CD26, PF4, Ncf1) may represent potential targets for the design of new therapeutic strategies.
Finally, the docking of two BBP molecules with distinct positions was necessary to fully account for the observed electron density, indicating that this molecule can adopt two alternate orientations in the LBP.
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We present a general method called dynamic single-molecule colocalization for quantitating the associations of single cell surface molecules labeled with distinct autofluorescent proteins.
Dual-color fluorescence cross-correlation spectroscopy (dcFCCS) allows one to quantitatively assess the interactions of mobile molecules labeled with distinct fluorophores.
The structures C-5 (form VI) and L-3 (forms I and II) are both binodal, i.e. they feature two sets of topologically distinct molecules, whereas the layer L-6 [23] contains three molecule types with distinct H-bond connectivity modes.
More generally, we suggest that molecules with three distinct functionalities may represent a practical upper limit on the extent of functionality present in the platform molecules that serve as the bridge between biological and chemical catalysis.
This process results in IgG4 molecules with 2 distinct antigen-binding sites [29].
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