These crystal sponges were tested on some small molecules, with two being unexpectedly difficult cases for analysis with in-house diffractometers in regard to data quality and proper space-group determination.
Most glycodendrimers have to be considered highly flexible molecules with their conformational preferences most difficult to elucidate by experimental methods.
Recognizing the cellular mechanisms impacted by cholesterol-lowering chemicals could help reveal additional molecular target(s) of these molecules, a difficult task associated with any cell-based screening processes.
As the size increases, the number of conformations available to the molecule also increases, making it difficult to pack the molecules with fewer defects.
But what actually happens within intact channels, which are enormous molecules with extensive real estate, rendering them notoriously difficult to study en masse?
In general, molecules with a high SAscore of >6 are difficult to synthesize [44], therefore, the majority of compounds constructed by eSynth can be considered as synthetically accessible.
The results suggest that binder molecules with increased selectivity can be obtained for difficult small molecule targets using the polypeptide conjugation technology.
MYC proteins are transcription factors that interact with their partner proteins and with DNA via large surfaces, making direct targeting with small molecule inhibitors difficult.
Although inhibition of transcription factors with small molecules has proven difficult (Berg, 2008), p97 is a druggable target (Chou et al., 2011, 2013; Magnaghi et al., 2013).
By the time Hodgkin was working it was possible, if difficult, to analyse huge biological molecules with all their complexity of packing.
