Sentence examples for molecules with broad from inspiring English sources

[ 30] The recent introduction of new molecules with broad spectrum of activity, low toxicity, and novel mechanisms of action such echinocandin is certainly favoring this strategy.

Nonetheless, circulating blood biomarkers should provide much of the most important information: organism‐level signaling occurs mostly through the circulatory and central nervous systems, and many of the classical biomarkers are critical regulatory molecules with broad roles, or are well‐known to be good general indicators of health state.

To identify molecules with broad anti-HK activity, we targeted the ATP-binding domain that is characterized by the Bergerat fold, a sandwich of α helices in one layer and mixed β strands in another, along with a discrete and flexible ATP lid.

In earlier work we identified a series of thiazolidinone inhibitors of the bacterial type III secretion system (T3SS) and demonstrated that this scaffold had the potential to be expanded into molecules with broad-spectrum anti-Gram negative activity.

Defensins are small peptides composed of cysteine-rich cationic molecules with broad-spectrum antimicrobial activity against bacteria, fungi and certain enveloped viruses [36].

Defensins are small peptides composed of cysteine-rich cationic molecules with broad-spectrum antimicrobial activity against bacteria, fungi and enveloped viruses [ 35].

Generally, it remains to be determined whether small molecules are required to specifically target only one molecule to be clinically useful or whether, in a manner similar to medically relevant kinase inhibitors, molecules with broader specificities against subfamilies of enzymes might exhibit clinical efficacy.

The antimicrobial evaluation revealed that the 5-fluorobenzimidazolyl derivative 5b was the most active antibacterial and antifungal molecule with broad spectrum in comparison to Berberine, Chloromycin, Norfloxacin and Fluconazole.

Squalene is considered today an interesting natural molecule, with broad applications in food industry and cosmetics and in prevention and treatment of human diseases.

379 molecules associated with broad cancer promoting mechanisms were found to be upregulated.

The screens identified molecules with both broad and narrow inhibition profiles, proving that protein kinase inhibitors offer privileged chemical matter with the potential to block antibiotic resistance.