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A large fraction of higher metazoan genomes transcribe RNA molecules whose functions extend far beyond carrying instructions for protein synthesis.
We can hypothesize that α6β4 integrin controls the translation of key molecules whose functions are strictly related to carcinoma survival.
Angiopoietin-1 (and1) and the antagonistic ligand angiopoietin-2 (are2) are important vascular regulatory molecules whose functions have been the subjects of intensive investigation.
ncRNAs have been described as a broad class of regulatory RNA molecules whose functions continue to be characterized in a variety of model organisms and diseases [ 15].
Such integrated approaches have also been found in case of other lnc-RNA molecules, whose functions are implicated in other cellular events [ 40].
Interestingly, most differentially expressed genes occur as nodes, while genes represented in hubs frequently encode transcription factors and signaling molecules whose functions may be modified by post-translational processing rather than by differences in levels of RNA or protein.
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NF-κB is a transcription factor involved in gene expression of many different inflammatory molecules whose function is crucial for microglial activation and induction of reactive astrogliosis.
This gene encodes major histocompatability complex (MHC) class-II β-chain molecules whose function is in the presentation of antigen to CD4+ T 'helper' cells.
In reactions specific to vertebrates, the extracellular molecules provide precursors for the biosynthesis of more complex molecules, whose function is in many cases characteristic of a specific cell type or tissue.
The MHC is the most polymorphic genetic system known in humans; it is divided into class I (HLA-A, HLA-B, and HLA-C) and class II (HLA-DRB1 and HLA-DQB1) molecules, whose function is to encode membrane glycoproteins that act as mediators in the presentation of antigenic peptides to lymphocytes T CD8+ and T CD4+, respectively, thereby triggering the immune response [ 13].
However, in view of the signaling capacity of ARF1 at the plasma membrane, it is possible that ARFGAP1, a molecule whose functions are intimately linked to ARF1, can regulate actin reorganization at the cell periphery.
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