Sentence examples for molecules which inhibit from inspiring English sources

Several laboratories show that it is feasible to design potent, nonpeptide, drug-like, small molecules, which inhibit protein protein interactions.

A primary goal in antimicrobial drug design is to find molecules which inhibit key proteins in bacteria without affecting mammalian homologues.

The selective elimination of these cells by artificial protein molecules which inhibit the production of Dpt-recognizing IgE antibodies is a perspective therapeutic goal of allergy.

However, the transcripts enriched in peripheral endothelial cells encode molecules which inhibit RXRalpha function, including secreted molecules, membrane receptors and cytoplasmic signaling components (Lbp, IL-1, Cd14, Myd6b, Nfp).

Many Rho functions have been elucidated using pharmacological inhibitors, the most prominent ones being Statins, molecules which inhibit isoprenoid intermediates production and Rho activation.

Those drugs molecules which inhibit the writhes preferably by inhibiting the synthesis of prostaglandins are considered as peripherally acting analgesic drugs [ 16, 30].

It has been shown that, in the absence of PD-1 in the mouse model of TB infection, PD-L1 binds to B7-1 molecules, which inhibits T cell proliferation and cytokine regulation [44], a finding that further support our observations in PD-1−/− mice.

Following a virtual screening campaign the results of the experimental evaluation confirmed the protocol quality, while the two most active molecules which inhibited mPGES-1 in a cell-free mPGES-1 activity assay, compounds 6 and 7, may serve as promising starting points for further optimization.

Ponatinib is identified as the more potent molecule, which inhibits DDR1 and DDR2 with an IC50 of 9 nM.

Another study showed that ICG-001, a small molecule which inhibits WNT/β-catenin signaling via interaction between β-catenin and CREB-binding protein (CBP), an intrinsic histone acetyltransferase to activate gene transcription, increased alveolarization and decreased vascular remodeling to develop pulmonary hypertension [104].

For instance, farnesol is a quorum-sensing molecule which inhibits pseudohyphae transition and biofilm formation in C. albicans [ 21, 22].