Sentence examples for molecules which bind from inspiring English sources

Currently, two classes of EGFR inhibitors namely monoclonal antibodies (mAbs) and small molecules, which bind to the extracellular ligand-binding domain and the intracellular tyrosine kinase domain of the EGFR, respectively, have been approved for the treatment of cancer patients (Modjtahedi and Essapen, 2009).

It was however difficult as some of the popular knowledge-bases like STITCH, the resource for chemical protein interaction networks (57), did not provide any information on the small molecules which bind the EBOV protein sequences, or those binding other similar proteins.

These antibodies are tagged with biotin molecules, which bind to the protein avidin.

Calnexin, calreticulin and ERp57 are also involved in the assembly of CD1d molecules, which bind lipids.

Small molecules which bind to and stabilize quadruplex DNA are thus being investigated as potential cancer therapeutics.

For example, the helper T cell produces and displays IL-2 receptors on its surface and also secretes IL-2 molecules, which bind to these receptors and stimulate the helper T cell to grow and divide.

To investigate the mechanisms of diminished receptor intensity, we tested the hypothesis that the initial round of CRAD infection in few cancer cells produced excessive amounts of free fiber molecules, which bound to receptors in both infected and non-infected cells, and thereby masked these receptors.

Because a biotin-antibody chemical link was made up of a dozen sp3 carbons, we assumed that mAb molecules which bound to the particle via the biotin anchor were free to rotate so as to find their target on the cell surface.

The regulation that we obtained using an extremely low energy transfer could result from a different synthesis and/or membrane distribution of adhesion molecules, which binds laminin (e.g. integrins).

36, 37 Instead of relying on targeting the ATP binding site, this study focuses on designing a molecule which binds to the PBD of Plk1 39, 39 in order to design a specific inhibitor.

Noggin is one such molecule, which binds tightly to the BMPs and prevents them from signaling (3).