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All molecules were screened for their in vitro cytotoxic activity on SW620 colon cancer cell lines.
The small molecules were screened via ThT, MTT, and cell-based cytotoxicity assay (Aβ burden assay).
When selected osteogenesis-related signaling molecules were screened, the PI3K-AKT-mTOR pathway was identified as potentially involved in P2X7R-enhanced PDLSC osteogenesis.
Also, the combinatorial library molecules were screened for toxicity in non-target organisms and degradability using USEPA-EPI Suite.
Subsequently, the molecules were screened for their antiproilferative effect against PC3 pancreatic carcinoma cells by adopting the 3- 4,5-dimethythiazol- 2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay method.
Regardless of their antagonistic potentials, all the synthesized molecules were screened for their anti-depressant potentials by using forced swim test in mice model; interestingly none of the tested compounds affect the locomotion of mice in the tested dose levels.
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An "in-house" chemical library of 4800 molecules was screened and five compounds with IC50 values in the micromolar range have been selected.
Together with the ZINC8 background, a total of 69683 molecules are screened by FINDSITEcomb.
A synthetic library of >500 cloned peptide toxins and related molecules was screened for inhibitory actions on mechanically activated currents in DRG neurons.
A diversity library of about 13,000 small molecules was screened using Autodock (v 3.05) for possible binders to uPAR and to the specific site on uPAR that binds integrin α5β1.
In step 3, the library of RNA molecules is screened.
More suggestions(15)
species were screened
suspects were screened
models were screened
particles were screened
cores were screened
clips were screened
molecules were designed
molecules were compared
molecules were considered
molecules were collected
molecules were synthesized
molecules were chosen
molecules were expressed
molecules were selected
molecules were shown
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