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Direct physical interactions with apoptotic molecules were demonstrated for HSPA1, HSPB1 and HSP90 [ 34, 35].
The specificity and the reactive nature of these molecules were demonstrated by mutating specific residues required for TRPA1 activation by electrophilic and reactive TRPA1 agonists.
Indeed, both molecules were demonstrated to inhibit HSP90 activity and HSP90 clients by a mechanism that is distinct from that of existing HSP90 ATP-binding pocket inhibitors.
Besides sulfhydryl groups, hydroxyl groups in small molecules were demonstrated to have some potential to form a ring structure with phenylarsine oxide in the gas phase.
Similar to some endogenous ligands such as 9- S -HODE, two magnolol molecules were demonstrated to cooperatively occupy the PPARγ LBD.
Nevertheless, transduction of MSCs with Ad5 was not detected, indicating that the integrin molecules did not play a role as an auxiliary receptor in MSCs although the integrin molecules were demonstrated to be the major receptor of Ad5 in CAR-deficient cells [ 23].
Similar(53)
Specificity of the small molecules was demonstrated by coimmunoprecipitation experiments for the lef-1/β-catenin interaction.
Potential utilization of the porosity for loading and delivery of antibiotic molecules was demonstrated, and the impact of selective etching on mechanical properties and hydrothermal stability was shown to be limited.
The modification of carbide derived carbon (CDC) thin film electrodes with anthraquinone (AQ) molecules was demonstrated by using pulsed chronoamperometry, in 0.1 M NEt4BF4/ACN solution of AQ diazonium derivative.
Although these nanoholes have lower sensitivity to refractive index compared to reported experiments in literatures, a higher sensitivity to biochemical molecules was demonstrated by this device due to the cone shape of the nanoholes.
Very recently, its enormous potential for producing complex fluorinated molecules was demonstrated by Chang and co-workers.
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