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Based on the crystal dimeric structure of HLA-DR molecules, we designed, and synthesized molecules able to induce the putative coreceptors dimerization.
To investigate the precise localization of cytoplasmic γ actin in skeletal muscle and the relationship to dystrophin molecules, we designed an antibody against the N-terminal peptide of cytoplasmic γ actin.
Based on the crystal structure of HLA-class II molecules we designed and synthesized a cyclic analog with restricted conformation, cyclo(Suc-Thr-Pro-Gln-Arg-Gly-Asp-Val-Lys -Thr-OH (Suc-Thr-Pro-Gln-Arg-Gly-Asp-Val-Lys -Thr-OHn with a Suc-Thr-Pro-Gln-Arg-Gly-Asp-Val-Lys -Thr-OH
Since the SYFPEITHI program only predicts binding of 15 amino acid sequences to HLA-DR molecules, we designed longer peptides by adding flanking residues in both ends that resulted in overlapping multiple epitopes for CD4 (15 amino acids) within one sequence.
To further test that (a) all the proteins used initially have encapsulated within the nanogel network and (b) the β-thiopropionate linker is responsible for the release of the encapsulated protein molecules, we designed and synthesized a control nanogel using a cross-linker that lacks β-thiopropionate functional group.
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Based on the NKX-2587 molecule we designed ten sensitizers with 1 10 thiophene moieties to investigate how the number of thiophene unit in the spacer influences the absorption spectra of sensitizer in dye sensitized solar cells (DSSCs).
To study S1 at a single-molecule level, we designed nanoparticle conjugates making use of the strong biotin-streptavidin interaction.
By leveraging the size based immobilization of atrazine small molecules we have designed electrochemical impedance spectroscopy based biosensor to detect trace amounts of atrazine.
To seek effective thermally activated delayed fluorescence (TADF) molecules, we have designed compounds 1-4 by introducing substituents on the para-position of boron atom of blue TADF molecule (DABNA-1).
To determine the intracellular distribution of Hfq molecules by EM, we designed an Hfq-MT fusion protein and expressed it in E. coli.
As a part of our research work towards development of biologically important hybrid molecules [ 27], we designed new curcumin analogues.
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