Sentence examples for molecules we applied from inspiring English sources
Based on these molecules, we applied rigid analogue and isosteric replacement approaches to design and synthesize nine new 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridine derivatives (2a i).
To create the conformational ensembles of the molecules, we applied the ConfGen tool of Schrödinger [38].
In order to quantify the level of similarity between the fingerprints of two molecules we applied the well-known Tanimoto-similarity coefficient [ 29].
In order to determine the molecular weight of intracellular ER molecules, we applied an in situ labelling approach along with an extraction procedure to minimize ER proteolysis [ 31, 32]; tumour slices were incubated with [I]TAZ at 37°C before homogenization and lysis at 100°C in the presence of SDS.
In order to understand the electronic transport in the molecule, we applied non-equilibrium green function (NEGF) method and performed Fowler-Nordheim (FN) and Millikan-Lauritsen (ML) analyses.
To increase the importance of low energy conformations on the final GMMs of a molecule, we apply the normalized Boltzmann distribution as given in Equation 8 to determine a probability value for a given conformer.
Working with n molecules, we can apply the mapping repeatedly to generate a succession of column vectors: ɸ L (d1),ɸ L (d2),⋯,ɸ L (d n ).
To examine the phenotypic changes caused by the loss of dystrophin, we applied antisense molecules to DMD-Myocytes to induce dystrophin protein expression by altering the splicing pattern to lead an in-frame shift achieved by an antisense oligonucleotide (AO) complementary to the target site31.
To verify the method for molecules with different diffusion speeds, we applied the RICS protocol to freely diffusing FluoSpheres and Alexa 488.
To understand the inhibitory mechanism of the inhibitor, we applied single-molecule dynamic force spectroscopy to reconstruct the energy landscape of NhaA.
We applied single-molecule detection and tracking methods to study the factors that control the mobility and clustering of phagocytic Fcγ receptors (FcγR).
