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Exact(5)
The pressure of the chamber was maintained at 10−6 Torr during dosing, and the number of exposed molecules was defined by the dosing time in seconds: 1 L (Langmuir) corresponds to 1 s dosing under 10−6 Torr.
Chamber pressure was maintained at 1 × 10−6 Torr during dosing, and the number of exposed molecules was defined by the dosing time in seconds: 1 L (Langmuir) corresponds to 1 s dosing at 1 × 10−6 Torr.
For this reason, we decided to filter the ligand set by excluding from the annotated binders: i) all the molecules co-crystallized with one of the receptor variants and ii) all the binders belonging to the same chemotype of a co-crystallized molecule (the chemotype of co-crystallized molecules was defined according to the rules reported in reference 34).
An abnormal elevation of the serum levels of the molecules was defined as any value above the mean value for the healthy group plus two standard deviations and an abnormal reduction as any value below the mean value for the control group minus two standard deviations.
The role of the molecules was defined by a hydrodynamic challenge with an NS3/4A-expressing plasmid, 30 in naive or vaccinated mice lacking specific genes involved in T cell priming or effector function (CD4 and CD8), T cell trafficking (TLR4 and IFNγ receptor-2), 36 and lytic killing of virally infected cells (perforin and FasL).
Similar(55)
The similarity of two molecules is defined as the difference of the number of atoms.
Cadherins and cadherin-related molecules are defined by having an ectodomain in which at least two consecutive calcium-binding cadherin repeats are present.
The similarity between two molecules is defined by any similarity coefficient (e.g. Tanimoto) available in SA2 applied to the selected fingerprint.
The ST [37 40] similarity measure, which quantifies the shape similarity between molecules, is defined as the following equation: ST = V AB V AA + V BB − V AB (5).
The prominent characteristics of the active molecules are defined, and the competition between cytochrome c, 4,4′-bipyridine, 1,2-bis(4-puridyl)ethylene and aldrithiol-4 for the adsorption at the gold electrode has been studied in particular.
In a PDB file, these molecules are defined within the HETATM record along with small molecule ligands, but for the purpose of our study they were not classified as drug-like.
More suggestions(15)
models was defined
compounds was defined
medications was defined
elements was defined
species was defined
particles was defined
molecules was conducted
molecules was calculated
molecules was observed
molecules was carried
molecules was confirmed
molecules was determined
molecules was kept
molecules was studied
molecules were defined
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