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Live cell imaging was also applied to study the specific binding of RGD peptide-conjugated PS-PEG micellar QDs with α v β3-integrin molecules, using an α v β3-integrin over-expressed cell line (U87 MG cells, purchased from KeyGen Biotech, China) versus a cell line without α v β3-integrin over-expression (MCF-7 cells, purchased from KeyGen Biotech, China).
As a step towards the synthesis of large libraries of NRP-like molecules using an in vitro translation system, we have studied the tolerance of the translation apparatus to a wide variety of amino acid analogs.
Here, we investigate the transgenerational dynamics of C. briggsae ΔmtDNA molecules using an experimental evolution approach.
However, in parallel to the tests conducted with the H 6-GFP BD-CVIL cell line, in vitro DXS activity from E. coli was determined in the presence of some of the tested molecules using an end-point assay, in which the remaining pyruvate substrate was converted to lactate by lactate dehydrogenase.
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Atomic force microscopy works by reading the electrical forces produced by molecules using a single, super-fine point.
Additionally, predictions can easily be made on new molecules using a single function call passing in a new structures file.
This chapter reviews the spectacular manipulations of single atoms and molecules using a low temperature scanning tunnelling microscope (STM).
To our best knowledge, this is the first reported study of these molecules using a combination of SERS/SEIRA.
A plot of the predicted activity versus experimental activity for molecules using a training set for structure activity relationship models is shown in Fig. 2.
We mimicked olfactory coding by modeling responses of primary olfactory neurons to small molecules using a large set of physicochemical molecular descriptors and artificial neural networks.
We extend our study to analyze common chemical substructures shared between biologically active molecules using a Maximum Common Substructure (MCS) approach.
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