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The overall objective of the present research was to develop a nanocarrier system for non-invasive delivery to brain of molecules useful for gene therapy.
To give just an example, the asymmetric allylation of tertiary α-fluoroketones, molecules useful for applications toward drugs, agrochemicals, and functional materials, was performed, inter alia, with chiral ferrocenyl catalysts (Figure 13, [43]).
Despite these limitations, AMPs are an important source of molecules useful for the design of new drugs.
Since bacteria are growing in a stressful environment and their metabolism seems highly compromised, expression of genes involved in the biosynthesis of molecules useful for replication is not essential.
These anthracenyl "carbofluorescein" and "carborhodamine 110" fluorophores exhibit excellent fluorescent properties and can be masked with enzyme- and photolabile groups to prepare high-contrast fluorogenic molecules useful for live cell imaging experiments and super-resolution microscopy.
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Therefore, CXCL12 seems to be a promising molecule useful for the presensibilisation of tumour cells in a combination-therapy of RCC.
The comparative study on the geometrical and electrostatic properties of these synthetic or natural molecules is useful for further designing new drugs for the better treatment of diabetes disease.
Taken together, we developed a convenient and highly sensitive ELISA-based HO-1 enzyme activity assay, allowing the identification and characterization of molecules potentially useful for the treatment of inflammatory and autoimmune diseases.
The obtained information of the electronic structure, the photophysical property and the chance of ESIPT of hetero nitrogen substituted HBX molecules is useful for molecular design of fluorescent molecular probes.
Our results indicate that engineered variants of Affibody molecules are useful for studying metal-binding and other properties of monomeric Aβ under various physiological conditions, which will improve our understanding of the molecular mechanisms involved in AD.
Computational tools for prediction of the secondary structure of two or more interacting nucleic acid molecules are useful for understanding mechanisms for ribozyme function, determining the affinity of an oligonucleotide primer to its target, and designing good antisense oligonucleotides, novel ribozymes, DNA code words, or nanostructures.
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