Sentence examples for molecules unable to from inspiring English sources

It is highly desirable to design ligand-dependent transcription regulation systems based on transactivators unresponsive to endogenous ligands but induced by synthetic small molecules unable to activate endogenous receptors.

Gene cassettes can exist in two forms: either as free covalently closed supercoiled circular molecules unable to replicate, or as linear molecules integrated at the attI1 site of integrons [2].

Hence, the primary reasons of large DNA molecules unable to be cloned into BAC vectors are probably due to damage to larger DNA molecules during the process of preparation and purification and subsequent preferential cloning of smaller DNA molecules [ 30].

Another challenge is a successful delivery of effective enzyme inhibitors into fugal cells, since inhibitors of enzymes of amino acid biosynthesis are often hydrophilic molecules, unable to cross the cytoplasmic membrane barrier.

With the aid of low molecular weight substrate molecules as mediators, oxidation by laccases can, however, be expanded to larger molecules unable to fit into the enzymatic pocket or even to non-phenolic compounds that are not actual substrates of laccases [ 14, 15].

In addition, labelling of the ligand can affect the binding properties and render the molecule unable to interact with the receptin.

Cr is a polar hydrophilic molecule unable to cross the lipidic membranes, which uses a Na +- and Cl −- dependent plasma membrane CrT to enter the cells (Nash et al., 1994).

It turns out that the mutant sodium channel mRNA molecules are unable to form RNA duplexes with potassium channel mRNA molecules: these duplexes would normally limit the number of potassium channels so, in their absence, the number of potassium channels increases, and this protects the flies from seizures.

Due to protein size and electrical charge, protein-bound molecules are unable to pass through the filter membranes and only unbound molecules will be available for elimination by CRRT.

As illustrated in Figure 4, although the movement of the molecules of benzyl alcohol (green circles) is quite fast, these molecules are unable to interact with the corresponding enzyme (aryl-alcohol dehydrogenase, named enzyme one and coloured yellow in the figure) unless the enzyme has already bound to a NAD+ molecule (i.e., creating the holoenzyme 1, coloured in black).

Small molecules tend to diffuse into the interior of the porous particles so that their flow is restricted, while large molecules are unable to enter the pores and tend to flow unhindered.