Sentence examples for molecules typical of from inspiring English sources

The best efforts of chemists to reconstruct molecules typical of life in the laboratory have shown only that it is a problem of fiendish difficulty.

Using TGFβ1 and BMP2 to induce chondrogenic differentiation in hMSCs in a self-gelling alginate scaffold system, we have recently shown that the differentiated cells upregulate the extracellular matrix (ECM) molecules typical of hyaline cartilage, and downregulate molecules typical of MSC functionality [ 26].

The GP has been suggested to have a key role in the induction of cytotoxicity and injury in endothelial cells, which is characterized by cell rounding and detachment associated by downregulating cell-adhesion molecules typical of anoikis.

Therefore, it is possible that senescent cells contribute to inflammation not only by producing proinflammatory and proangiogenic molecules typical of SASP but also by transferring miRs into other proinflammatory cells, namely, macrophages [ 119].

As placental pathologies, including PE and IUGR, are characterized by altered expression of key regulators of trophoblast cell fate such as Mcl-1 and p53, we hypothesized that changes in MULE expression and activity may contribute to the altered balance in pro-survival and death-inducing molecules typical of these pathologies.

In our previous study directly focusing on the expression of putative stem cell markers in EMT-derived tumour cells, we describe a low frequency of CD44s, CD166, and EpCAM staining within tumour buds, thus emphasising the loss of cell adhesion molecules typical of these cells (Hostettler et al, 2010).

The results obtained here demonstrate clearly that simple, 2D fingerprint representations provide measures of structural similarity that mimic closely the judgments of experts, using both training-set molecule-pairs extracted from DrugBank and test-set molecule-pairs typical of the work of the CHMP.

The spectra showed a range of resonances from small molecule metabolites, typical of tissue extracts.

By comparison, the Fe S bond length seen in IsdE, which coordinates heme-iron using Met and His, is shorter at 2.3 Å. (40) The Fe–O bond length (Tyr heme-iron) observed in IsdB-N2, which ranges from 2.1 Tyr heme-ironnding observedolecule, in typical of those seen in other NEAT domain structures: 2.1 Å for IsdA-N1,(40) 2.2 Å for IsdH-N3,(12) and 2.0–2.1 Å for IsdC-N1.

The roles, mechanisms of action, and involvement in pathogenesis of individual chaperonin molecules beyond those typical of their canonical oligomeric complexes constitute aspects of chaperonin physiology particularly promising for future experimental testing.

There are only a million molecules (of typical size) per layer per square micrometer.