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Exact(5)

The further attachment of other functional molecules to this system should enable various other potential functionalities.

A high local concentration of Arf GTP with lowered off-rate is obtained that can recruit effector molecules to this precise location where budding is in progress.

As a major component of hypertrophic zone, type X collagen influences deposition of other matrix molecules to this region and thereby provide a proper environment for hematopoiesis, mineralization and modeling that are essential for endochondral ossification.

Also, PHD HD1 has a strong tendency to engage in pseudoligand interactions through its histone-binding surface, e.g., with lysine-containing peptides from symmetry-related proteins, which could hinder the access of small molecules to this surface.

The binding of monomeric NEMO44 111 des3C) to IKKβ can notionally be separated into two steps: (1) association of two disordered monomers to form an ordered noncovalent coiled-coil dimer, with free energy Δ GDimeriz, and (2) binding of two IKKβ molecules to this noncovalent dimer to form the final complex.

Similar(55)

However, it is clear that the binding of a small molecule to this site would disrupt the ability of Hsp90 to undergo N-terminal dimerization.

The remaining cysteine (Cys 17) is not disulfide-linked but efforts to attach a PEG molecule to this site resulted in decreased activity.

Therefore, the data obtained with bactosomes are consistent with a model where the maximal rate of CBZ metabolism is obtained by the complex of CYP3A4 with one substrate molecule, and the subsequent low-affinity binding of a second CBZ molecule to this complex results in an ca. 5-fold decrease in the rate of CBZ metabolism.

They did this by creating special molecules to deliver this amino acid to the cell's protein-making machinery.

Designing small molecules to block this interaction would lessen the effects of Aβ neurotoxicity.

AQPs can act as key candidate molecules to confront this issue.

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