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Coupling of small molecules or peptide derivatives to antibodies that bind to tumor cell surface antigens is also applied to direct potent small molecules to target cells (e.g., in form of tumor-targeting cytotoxic antibody-drug conjugates (7– 12).
FACS and MACS methods utilize differences in cell surface molecules to target specific cells using antibodies.
Many pathogens use surface molecules to target specific cell types in the gut for host invasion.
However, several barriers restrict the permeation and bioavailability of these molecules to target tissues.
Gene therapy is an efficient method for delivering therapeutic molecules to target cells.
Aminoglycosides are the most well studied class of small molecules to target RNA.
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The investigators then designed another hybrid molecule to target the skipped exon of SMN2, a gene involved in spinal muscular atrophy, and they had similar success.
Protein neddylation is a newly characterized protein posttranslational modification in eukaryotic cells by adding NEDD8, an ubiquitin-like molecule, to target proteins [ 5– 8].
The ChEMBL data model links molecules to targets using different activity types recorded in the literature.
For queries which link small molecules to targets, by traversing bioactivity data in the ChEMBL database, it is also important to consider the parameters associated with the assay to target mappings.
These molecules bind to target molecules and block specific or nonspecific intramolecular interactions that cause secondary structure formation.
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