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The invariant chain (Ii) is an important immune molecule, as it assists major histocompatibility complex (MHC) class II molecules to present antigenic peptides.
As professional antigen-presenting cells, macrophages not only respond to Th1 and Th2 cytokines and alter their functional phenotypes, but also secrete different amounts of M1 and M2 cytokines and express antigen uptake and presenting related surface markers (such as mannose receptor, MHC and costimulatory molecules) to present antigen protein and activate T/B cells13, 33.
Our results suggest that the intrinsic preference of different HLA molecules to present p24 peptides explains why some HLA molecules are more protective than others.
Similar to peptide-DCs, priming of CD8+ T cells by ActOVA DCs was inefficient in mice with endogenous cells lacking the appropriate MHC molecules to present the OVA257 264 peptide (Fig. 2C and Fig. 3A).
Since the transferred KbDb-/ MEFs lacked any class I MHC molecules to present viral antigen, mice receiving ΔgL infected fibroblasts should only mount a CD8+ T cell response if endogenous cells can capture and cross-present viral antigen in class I MHC.
Most Xenopus species have a single-expressed MHC Class I gene (Class Ia), which encodes receptor molecules to present intracellular pathogen and is closely linked to other genes assisting in antigen processing.
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CD1 molecules function to present lipid-based antigens to T cells.
A subset of MPS cells express the endocytic receptors, intracellular trafficking and processing pathways, and cell surface major histocompatibility complex (MHC) molecules required to present antigen to T lymphocytes.
These chemical templates (also called infoboxes) are pieces of Wikipedia markup embedded into chemistry pages that contain the most important information about molecules, allowing to present chemical data in a standardized way and support also computer mining of the data.
MHC molecules function to present foreign antigens.
HLA genes encode cell surface molecules specialized to present antigenic peptides to T-cell receptors.
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