Sentence examples for molecules to perturb from inspiring English sources
New chemical methods that use small molecules to perturb cellular function in ways analogous to genetics have recently been developed.
The ability of small molecules to perturb the natural structure and dynamics of nucleic acids is intriguing and has potential applications in cancer therapeutics.
An activated form of the response regulator CheY destabilizes the parallel arrangement of FliM molecules to perturb FliG alignment in a process that may reflect the onset of rotation switching.
Indeed, the ability of these small molecules to perturb multiple signaling proteins may be an essential aspect of their cellular phenotypes.
Due to restrictions of space, this Account will focus primarily on our own efforts to develop small molecules to perturb, profile, and perceive glycans.
As the field progresses, the importance of aberrant TCA cycle function in tumorigenesis and the potentials of applying small molecule inhibitors to perturb the enhanced cycle function for cancer treatment start to evolve.
To investigate the possibility that the observed long-range coexpression signal was unique to genetic variation studies, we examined a set of samples (2335) in which a series of small molecules was applied to perturb a single cell line MCF7 [11].
Gal4/UAS-based expression of this molecule was reported to serve to perturb wild type DE-Cadherin function [19].
Thus, the therapeutic effect of anti-HER2 treatments can likely be modulated using small molecule inhibitors or genetic methods to perturb the balance between pro-apoptotic and anti-apoptotic signaling.
There are numerous intracellular targets and protein protein interactions with large flat contact areas; these are considered difficult to perturb by small molecules.
Additionally, for those herpesviruses with tropism to immune effector cells, it is of interest either to reduce the overall expression or to perturb the endosomal trafficking of immune recognition molecules (i.e., TCR/CD3, CD4 molecule, costimulatory molecules, adhesion molecules) and thereby, reduce their cell surface expression.
