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He and his colleagues screened libraries of small molecules to find ones similar to the protective protein subunits.
"I was prepared to screen tens of thousands of molecules to find the right one," Seyedsayamdost says.
Tutorials enable the reader to practice disconnecting target molecules to find the 'hidden' biocatalytic reactions which can be applied in the synthetic direction.
They're also continuing to sort through new variants of the molecules to find ones that work better, and they're testing the effectiveness of the delivery agents for targeting different diseases and for delivering different therapeutics in addition to RNA.
They are screening hundreds of thousands of molecules to find ones that can enhance certain tastes, such as sweet or salty, with the hope of concocting foods that are kind to our waistlines but still excite our palates.
To an outsider, the exploration of thousands of molecules to find a small number of potential candidate drugs must appear enormously wasteful, but many medicinal chemists would defend this waste as unavoidable.
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Dye molecules were found to cover both the inner and outer surface of the bamboo type TiO2 NT arrays.
That creates far more places for the occasional explosives molecule to find a home.
Then came many years of investigating other modifications of the thymidine molecule to find compounds that might stop the growth of aberrant DNA and could be used as anticancer agents.
This elite cohort of molecules was then simulated, at a rate of about 12 hours per molecule, to find out more or less how bright and how blue each was likely to be.
A simulation length of 10 ns was used in the study to allow rearrangement of the ligand bound protein molecule to find its stable binding mode.
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