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We have used this assay in conjunction with cocrystal structures of small molecules to drive a structure-based design program aimed at the discovery and optimization of a novel class of potent Hsp90 inhibitors.
The catalysts and methods developed in the group are being applied to the synthesis of biologically active molecules to drive the development of new chemistry as well as help to address problems in human health.
It is expected that USP8 mutations deregulate these molecules to drive ACTH production and secretion.
Under conditions of low AA concentrations, 5-LO is unable to produce a sufficient quantity of HP molecules to drive the transition of the enzyme to active form.
Linking the acetyl molecules into fatty acid chains and then to the glycerol head (section 6.2-1) requires 137 ATP molecules to drive the synthesis.
It reminds us that E2 is formed by two steps of Fe → MoFe protein ET, with each step involving hydrolysis of two ATP molecules to drive a reaction that is highly "uphill" energetically.
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Tks5, an indispensable adaptor protein for Src-induced cancer cell invadopodia formation was shown to be a key molecule to drive those fusion processes.
This is mainly due to the fact that the hydrogen-bonding interactions of the polar and spH1 H-atoms with other charged groups (including solvent molecules) tend to drive the H-atoms away from the locally optimal position with minimum steric repulsion.
The lab is able to replace platinum catalysis with iron catalysis by adding an organic molecule that encapsulates the smaller iron molecule, helping to drive the reaction.
These molecules are considered to drive the cell cycle by activating CDK2 [ 23].
We focused our attention on the cadherin family of cell adhesion molecules as candidates to drive the sorting and segregation of cranial motor nuclei, as they play key roles in the organization of spinal lateral motor column neurons [ 15 21].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com