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Furthermore, the contact printing based technique can be utilized in combination with diffusion of the aminosilane molecules to directly create its gradient, and consequently a nanoparticle density gradient.
Molecule screening at the single cell level, which is critical in molecular biology and drug discovery, requires that target molecules be introduced into single cells to permit cellular-function-targeted molecules to directly regulate cell development and their functions to be quantified.
First, SCR peptides may form interactions with endogenously produced SCR molecules to directly inhibit their activity.
In addition, the primary metabolic pathways play a role as a source of signaling molecules to directly or indirectly trigger defense responses.
Another approach to intracellular delivery uses physical forces to transiently and reversibly disrupt the cell membrane, thereby allowing molecules to directly enter the cytoplasm of cells either by diffusion or, in some cases, by electrophoretically driven processes through short-lived transmembrane pores.
Together, these studies highlight the growing field of regenerative medicine in zebrafish, which will enable the elucidation of signals that make repair possible in those organs that typically do not regenerate in mammals, and identify novel molecules to directly enhance regenerative processes already utilized in clinical medicine today.
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The performance of the new setup was demonstrated in a photodetachment experiment, making use of the small electron affinity (EA = 26 ± 5 meV) [8] of the NO molecule to directly deplete ions from a fast ion beam.
Over a period of time, the genetic information in RNA sequences was transferred to DNA sequences, and the ability of RNA molecules to replicate directly was lost.
In these cases special holes in the membrane, called channels, allow specific ions and small molecules to diffuse directly through the bilayer.
The next steps are to use new techniques such as single-molecule imaging to directly visualize the molecules involved in transcription, and to use the new molecule to block the start of transcription in living cells.
To this aim, we defined a pharmacology training set of 25 compounds containing 3 small molecules reported to directly engage AR as antagonists, and a range of compound classes targeting AR co-regulator proteins.
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