Sentence examples for molecules to block from inspiring English sources
Designing small molecules to block this interaction would lessen the effects of Aβ neurotoxicity.
The company has figured out the three-dimensional structure of the beta enzyme and is fashioning molecules to block its activity.
The compact β-hairpin binding pocket within the immunity protein represents a tractable system for the rationale design of small molecules to block CdiA-CT/CdiI complex formation.
He won for the idea of creating high-affinity SIRP-alpha molecules to block the CD47 "don't eat me" signal that keeps macrophage cells from consuming and destroying cancer cells.
But very quickly, complex biochemical processes spring into action, creating a scaffolding of molecules to block the hole, and then building up an impervious clot to stanch the flow.
There are now more than a dozen liposomally packaged drugs on the marketplace, and researchers have begun to explore ways to use other types of nanoparticles to deliver not just drugs, but also small RNA molecules to block the expression of specific genes, or a payload of radioactivity to kill the cell.
The authors infer that the gate opens to allow LPS to slide past, but then spontaneously closes behind the molecule to block any backward flow, much like the pawl mechanism of a ratchet.
This large interface requires a high-affinity small molecule to block it.
The next steps are to use new techniques such as single-molecule imaging to directly visualize the molecules involved in transcription, and to use the new molecule to block the start of transcription in living cells.
Specifically, the manuscript addresses and answers an interesting question in the field-that is the mode of action of ISRIB, the only currently available small molecule to block eIF2∼P regulation of translational initiation.
Strategies aimed at harnessing the inflammatory response in preclinical models of PD have included use of anti-inflammatory gene therapy approaches: overexpression of a dominant negative TNF molecule to block native TNF signalling has been shown to effectively protect neurons from 6-OHDA-induced cell death even after delayed administration [ 104, 105].
