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The evolution of receptors has accompanied the development of mechanisms that permit external chemical signaling molecules, the first messengers, to direct the activities of cells in a variety of ways with high specificity and precise control in terms of extent and duration.
On the other hand, (C) yielded two types of molecules: The first group (marked * in Figure 3) deleted some conventional IESs, with no segments unscrambled.
Our experiments show that upon mixing actin monomers with Arp2/3 complex, VCA and fascin molecules, the first structures to appear in solution are dense and highly branched aster-like networks of actin filaments [27].
Since surfactants are amphiphilic molecules, the first locus of their interaction with cells of any kind is the cell membrane and this interaction is related to their partition coefficient between the aqueous and membrane phases which, in its turn, is related to the Critical Micelle Concentration (CMC) of the surfactant.
Among such molecules, the first identified one is the myeloid differentiation factor 88 (MyD88).
These are ubiquitously expressed, essential enzymes performing the attachment of amino acids to their cognate tRNA molecules, the first step of protein synthesis.
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The first similarity measure is based on the size of the maximum common substructure (MCS – e.g., Raymond et al.[4]) of two molecules, the second is based on Extended Connectivity Fingerprints (ECFP) [5].
For static molecules, the second gradient pulse will be able to compensate the phase shift produced by the first one; no additional shift is generated from movement.
Given coordination by residues from two separate VIM-2 molecules, the third Zn II) binding site is likely a crystallographic artifact.
Two monoclonal antibodies were prepared against sterically remote antigenic sites on the TAG 72 molecule: the first was coated on the ELSA solid phase; the second, radiolabeled with iodine 125, was used as tracer.
3M imidazoquinoline (IRM) molecules were the first synthetic small molecules identified as TLR agonists and can affect their biological activities through TLR7, TLR8, or both.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com