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RNA-cleaving phosphodiester-linked DNA based enzymes (DNAzymes) are catalytic DNA molecules that specifically bind to and cleave targeted mRNA in a sequence-specific manner.
The graphene layer is adorned with molecules that specifically attach to mercury and when they do, a rapid change in electrical current can be detected.
Cellular and molecular processes of interest are identified by bioengineered nanoparticles or small molecules that specifically detect the desired target.
We believe the structural clues identified in this study can be used to identify novel peptidometics and small molecules that specifically target ER dimer interface generating a new breed of anti-cancer agents.
The second screen contains small molecules that can affect the folding, aggregation state and solubility of the protein construct and also includes small molecules that specifically bind and stabilize proteins.
Finally, we summarize recent advances in the design and application of a number of molecules that specifically target individual RhoGTPases or their regulators or effectors, and discuss their potential for cancer therapy.
Similar(23)
MEL050 is a synthetic benzamide-derived molecule that specifically binds to melanin with high affinity.
Moreover, we suggest that PPP, a small molecule that specifically interferes with IGF-IR function, is a potential effective therapy.
Apremilast (CC-10004; Celgene Corporation, Summit, NJ, USA) is a small molecule that specifically inhibits PDE4, thereby elevating intracellular cAMP levels.
A previous study reported that the inhibition of the deubiquitinating activity of HAUSP using a small molecule that specifically inhibits HAUSP resulted in apoptosis in multiple myeloma (MM).
We used β-galactosidase staining or 5-dodecanoylaminofluorescein di- β-𝒟-galactopyranoside (C12FDG), a membrane-permeable molecule that specifically stains senescent cells, to evaluate senescence.
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