Several factors have been shown to be capable of enhancing satellite cell activation, including growth factors, small molecules that modulate signaling pathways, immune modulation, and physical exercise.
The first level, growth factor modulators (GM class), are secreted molecules that modulate the activities of receptor-binding secreted factors.
We realised that discovering molecules that modulate the location of these proteins would provide a novel way to treat such diseases.
The development of small molecules that modulate the stability of G-quadruplex structures has a potential therapeutic interest in cancer treatment and prevention of aging.
Metabolic flux is in part regulated by endogenous small molecules that modulate the catalytic activity of an enzyme, e.g., allosteric inhibition.
These advances have allowed the rational design of small molecules that modulate the cell cycle by competing for sites of protein protein or protein ATP interactions.
Small molecules that modulate stem cell fate and function offer significant opportunities that will allow the full realization of the therapeutic potential of stem cells.
A promising way to interfere with biological processes is through the control of protein-protein interactions by means of small molecules that modulate the formation of protein-protein complexes.
It is now well known that aberrations in the epigenome can contribute to a variety of diseases, and thus discovery of small molecules that modulate the epigenome in a specific manner is an important undertaking.
In this review, we analyze the 21 experimentally determined three-dimensional structures of the known peptide-binding GPCRs in relation to the endogenous peptides and drug molecules that modulate their cell signaling processes.
This data has provided new insights into the binding and cleavage of C4 by MASP-2, which may be useful in the design of molecules that modulate this important interaction required to activate the lectin pathway of complement.
