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These ions, being electrically charged, attract shells of water molecules that increase their effective diameter.
This modulation, in turn, can be achieved by bioactive molecules that increase osteoblastic differentiation and accelerate bone healing around the implant [2].
Thus, we designed a high-throughput chemical screen platform to quantify PGC-1α acetylation in cells and identified small molecules that increase PGC-1α acetylation, suppress gluconeogenic gene expression, and reduce glucose production in hepatocytes.
Increases in bone formation have been demonstrated in mice and rats treated with statins, a group of molecules that increase the production of bone morphogenetic proteins-2 (byP2) by stimulating its promoter.
Enzyme activity can be affected by other molecules: inhibitors are molecules that decrease enzyme activity, and activators are molecules that increase activity.
Enzyme inhibitors are molecules that reduce or abolish enzyme activity, while enzyme activators are molecules that increase the catalytic rate of enzymes.
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It was found that ligands inducing cAMP synthesis activate genes involved in cell growth and proliferation; cAMP and Ca2+ molecules that increased together form a feedback loop and induce immune cells to migrate and adhere together.
We identified small molecules that increased the appearance of TH+ neurons in the assay, including those with known neurotrophic activity and those that are functionally novel.
The Fischbach lab had just discovered neuregulin, a molecule that increased nicotinic receptors at the neuromuscular junction.
Theobromine, a caffeinelike molecule that increases blood flow to the brain, is so hard for dogs to process that they can easily eat enough to be poisonous.
Our previous study identified SENP3 as a redox sensitive molecule that increased its abundance under various conditions of oxidative stress (Huang et al., 2009).
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CEO of Professional Science Editing for Scientists @ prosciediting.com