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Forward chemical genetics involves screening a library of compounds to find small molecules that generate a consistent phenotype in a biological assay, analogous to more traditional genetic screens.
We isolated molecules that generate unique binding patterns sufficient to unequivocally identify any of the tested human glioma cell lines analyzed and to distinguish high from low or non-tumorigenic cell lines.
In this case, breakage of the stalled fork located on the large part of the AflIII fragment should result in a series of asymmetric Y molecules (arcD, Fig. 2C) similar though not identical to the population of molecules that generate a simple Y pattern, as demonstrated elsewhere [32].
Drinking water disinfectants include highly reactive molecules that generate undesired compounds through reaction with organic matter.
Multiphoton autofluorescence imaging is usually carried out with laser illumination in the 700-800 nm range since the majority of the biological molecules that generate multiphoton intrinsic fluorescence signals absorb maximally at these wavelengths [ 4].
In initial experiments, we determined the minimal concentration of α-actinin molecules that generate sufficient load to stall the movement of actin filaments for a given surface density of myosin heads.
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The intensities of the two spectra only seem to be comparable, since the number of molecules that generated the signals was very different.
This apparent discrepancy is caused by post-translational glycosylation, with the majority of the glycosylation being concentrated in a region of the porcine enamelin molecule that generates the so-called '32-kDa enamelin'(11).
Shin Maeda (Yokohama City University, Yokohama, Japan) gave keynote lecture 2. E-cadherin (Cdh) is an important cell-cell adhesion molecule that generates adherence junctions; however, its role in tumor development remains controversial.
By fusing proteins to enzymes that generate reactive molecules, most commonly biotin, proximate proteins are covalently labeled to enable their isolation and identification.
A systematic approach is required to help identify the physiologically relevant vasoinhibin molecules and the cleaving proteases that generate them.
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models that generate
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elements that generate
species that generate
molecules that help
molecules that carry
molecules that differ
molecules that pass
molecules that build
molecules that give
molecules that target
molecules that average
molecules that interfere
molecules that do
molecules that perform
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CEO of Professional Science Editing for Scientists @ prosciediting.com