Sentence examples for molecules that directly from inspiring English sources

In addition, we have identified four small molecules that directly inhibit Smo activity but are structurally distinct from cyclopamine.

We discover and develop small molecules that directly bind and modulate 'undruggable' transcription factors or their protein partners.

However, small molecules that directly target the most common misfolded CFTR mutant, ΔF508, and improve its intracellular trafficking in vitro, have shown modest effects13.

These strategies are commonly focused on the identification of molecules that directly target mutant CFTR.

Ovarian cancer-derived EVs carry molecules that directly regulate cancer cell migration, including CD24, EpCAM, and soluble activated leukocyte cell adhesion molecule (sALCAM) and soluble L1 (Carbotti et al., 2013; Gutwein et al., 2005; Runz et al., 2007).

However, small molecules that directly target the most common misfolded CFTR mutant, F508del, and improve its intracellular trafficking in vitro, have been less effective than expected when tested in CF patients, even in combination with Ivacaftor.

Our method involves circularization of a specific genomic DNA molecule that directly incorporates the necessary components for conducting sequencing in a single assay and requires only one PCR amplification step.

While tropoelastin is a flexible molecule, a combination of optical and structural analyses has defined key regions of the molecule that directly contribute to the elastomeric properties and control the cell interactions of the protein.

Small molecule therapy inhibition of cancer protein production There is an array of small molecules that can inhibit the development of cancer at different points of a cell's manufacture of the molecule that directly leads to a cell becoming cancerous.

One question that may arise is the identification of the adaptor molecule that directly interacts with AQP5 to exert its alleged effects in CML.

Currently, two different approaches are being used: a molecule that directly activate p53 by blocking protein-protein interactions and compounds that trigger indirectly the stimulation of TP53 system [46] such as Nutlin-3, a small molecule antagonist of MDM-2 that disrupts the MDM2-p53 interaction resulting in p53 stabilization and activation of p53 function [47].