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Many water-soluble molecules that cannot penetrate the lipid bilayer are too large to fit through open channels.
Because biologics are large, complex molecules that cannot be exactly duplicated, biosimilars cannot be considered "generic" versions of biologic drugs.
Hydrothermal fluids most likely contain other organic molecules that cannot be recovered and / or detected using the current method.
The first step is done using a database query that filters out the molecules that cannot match the query.
The immune system is capable of recognizing and responding to microorganisms and molecules that cannot be perceived by our sensory mechanisms, which send stimuli straight into the brain.
As a result, it can be used for calculating the descriptors for large molecules that cannot be calculated using other software.
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A molecule that cannot be loaded by the handler (e.g. invalid format) will not be imported into the database (an error message informs the user on each problematic molecule).
If one assumes that the av6J deletion generates an entirely non-functional molecule that cannot interact with CDH23, one could argue that PCDH15 is not required for either tip link formation or transduction, despite accumulating evidence (including the data presented above) suggesting otherwise.
The attachment of E2 to a large molecule that cannot easily enter cells has previously been used to demonstrate action at the membrane [ 30- 33].
Moreover, the aromatic substrate promiscuity of this variant could be improved when the environment of the catalytic tryptophan was engineered by seven additional mutations resulting in a second variant, whose activity on RB5 (a recalcitrant molecule that cannot be oxidized by LiP) was several fold higher than that found for the best VP, when the reactions were performed at the optimal pH values.
A more rigorous test to verify which cleavage in prothrombin is affected by the deletion at the COOH terminus of factor Va heavy chain involves the study of the activation of a prothrombin molecule that cannot be cleaved at Arg such as rMZ-II (41).
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