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The 16H and 24H molecules that bound only one Ku heterodimer were almost as inefficient as the short 8-bp (8H) Dbait that did not bind Ku.
During the 2nd selection step, we found that enrichment of specific peptide sequences was difficult due to an abundance of molecules that bound to MDM2 in the library.
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To fight infections, some scientists hope to design or find molecules that bind to the bacterial sensors, blocking out the signaling molecules.
This technology provides a relatively rapid means of generating novel antigen-binding molecules that bind strongly to immobilized antigen.
These highly constrained scaffolds reduce entropy in the system, leading to smaller molecules that bind tighter to their targets.
However, the high orientation component also appeared beyond the critical strain; it could be assigned to the so-called "tie molecules" that bind the deformed lamellae.
In case of colloidal QDs, chemical self-assembly based on long organic molecules that bind to the functionalized surface of a metal nanoparticle is often used [10].
For simple cage molecules that bind upright on the substrate, tilt domain boundaries found in linear chain systems are completely eliminated.
Molecular dynamics simulations can be used to model the biologically relevant conformations and virtual screening can then be used to select for small molecules that bind specific conformations.
Antibodies represent a highly successful class of molecules that bind a wide-range of targets in therapeutic-, diagnostic- and research-based applications.
Bacterial riboswitches are elements present in the 5′-untranslated regions (UTRs) of mRNA molecules that bind to ligands and regulate the expression of downstream genes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com